Iobion Informatics LLC

IOBION INFORMATICS AND AFFYMETRIX SIGN CO-MARKETING AGREEMENT TO PROMOTE ARRAYASSIST TM SOFTWARE FOR GENECHIP® MICROARRAY DATA ANALYSIS

ArrayAssist further extends the Affymetrix platform with its extreme ease of use and strong data analysis features.

La Jolla, Calif. - January 6, 2003 - Iobion Informatics announced today that ArrayAssist has been designated an Affymetrix Premier Application. The Premier Application rating is part of a new Affymetrix Provider program that recognizes software tools that extend and enhance the Affymetrix platform and provide exceptional value to the life sciences community.

ArrayAssist is a desktop application for the analysis of Affymetrix GeneChip® microarray data designed specifically for the research biologist. "We have worked hard to build a powerful analysis tool using the latest probe-level algorithms and tightly integrated with the Affymetrix platform." said Jason Goncalves, Chief Scientific Officer, Iobion Informatics. "However, extreme ease of use is what really sets ArrayAssist apart from other microarray analysis tools."

"Iobion's ArrayAssist software is among the first software packages to receive the Affymetrix Premier Application rating," said Scott Jokerst, Senior Product Marketing Manager at Affymetrix. "We found that ArrayAssist was exceptionally easy to use, integrated seamlessly with the Affymetrix platform, and offered strong analytic capabilities that were accessible to biologists. We believe Iobion's software will enable life scientists to make better decisions with their GeneChip microarray data."

ArrayAssist, part of the IobionLab™ suite, is sold and distributed by Stratagene.
For more information on the ArrayAssist product or the IobionLab software suite visit www.stratagene.com/softwaresolutions.

About Iobion
Iobion Informatics is a Stratagene Affiliate developing software solutions for science. Iobion combines its expertise in biological science with information technology to develop powerful, user-friendly software packages that enable scientists to efficiently examine, interpret and store data for the advancement of knowledge. The company offers several products under its GeneTraffic™ and IobionLab™ brand. Iobion is headquartered in La Jolla, California and has offices in Toronto, Canada. More information is available at www.iobion.com.

About Stratagene
Stratagene is a worldwide leader in developing innovative products for life science research. As a privately held biotechnology company, Stratagene supports advances in science by inventing, manufacturing and distributing products that simplify, accelerate and improve research. Since 1984, Stratagene's products have been used throughout the academic, industrial, and government research sectors in fields spanning molecular biology, genomics, proteomics, drug discovery and toxicology. More information is available at www.stratagene.com.

IOBION ANNOUNCES AMDeC's ADOPTION OF GENETRAFFIC SOFTWARE PLATFORM

La Jolla, CA, October 3, 2002 - Iobion Informatics announced today that AMDeC Foundation, Inc., a consortium of thirty-nine of New York's world-renowned medical schools, academic health centers, and other research institutions, has adopted GeneTraffic. This deal enables AMDeC affiliated researchers to analyze and share data across institutions, ultimately leading to larger collaborative projects and standardized research protocols.

Iobion's GeneTraffic software stores raw microarray data files, which includes numerical and image files, provides built-in data management, and facilitates data validation and analysis. AMDeC's microarray resource center, run by Dr. Andrew Brooks of the University of Rochester, will use GeneTraffic Multi as their platform of choice for its combined capability of handling microarray data from Affymetrix® GeneChip® and spotted array experiments.

"While it was Iobion's implementation of a 'Start to Finish' microarray data management and analysis capability in GeneTraffic that first received notice by AMDeC-affiliated investigators," stated Dr. Brooks, "it was Iobion's ability to deliver on-time the GeneTraffic Multi software product, incorporating leading-edge data analysis approaches within a multi-user graphical user interface, that really impressed the thought-leaders at AMDeC."

"This deal represents another significant milestone in AMDeC's efforts to ensure that New York's scientists have affordable access to today's cutting-edge research technologies, and is a critical step in our efforts to position New York to lead the nation in the new genomic era," said Maria K. Mitchell, Ph.D., president of AMDeC.

"With the breadth of functionality in a single software package, installing from a single CD, scientists can load, store, investigate, visualize and analyze their data from any computer on their Local Area Network," comments Stephen Sharp, Director of Marketing Iobion Informatics. "This architectural design facilitates the installation and use of the software in research laboratories, yielding a high return on investment (ROI)."

About AMDeC
AMDeC was developed by leaders in New York's medical and scientific community to establish New York as the international center for biomedical research and technology over the next decade. Through AMDeC, its thirty-nine affiliated institutions are working collaboratively to develop large-scale basic science and clinical research projects, expand New York's research infrastructure, recruit talented researchers to New York's scientific institutions, further develop New York's biotechnology sector, and pursue research-related business opportunities. This deal with Iobion represents one of the business arrangements AMDeC has negotiated on behalf of its member institutions that will help foster research collaborations and produce more cost-effective and far-reaching research in New York.

Iobion's GeneTraffic™ software product is mentioned in a recent O'Reilly bioinformatics publication.

Developing Bioinformatics Computer Skills
Authors: Cynthia Gibas & Per Jambeck
O'Reilly and Associates, 2001

Page 51:
"If you're looking for a complete, self-contained bioinformatics system, Iobion Systems is developing" GeneTraffic™, "a ground-breaking bioinformatics network server appliance developed using open source technologies."

Iobion is not associated or affiliated with O'Reilly.

CANVAC Gene Expression Database

A daunting task for many researchers starting microarray experiments is the storage and analysis of the vast amounts of data that can be rapidly acquired. In 2001, the CANVAC (Canadian Network for Vaccines and Therapeutics) microarray core facility has worked closely to implement Iobion Informatics' GeneTraffic software to develop a centralized data storage and analysis server that provides secure nationwide access to experimental data. Through the relational database in GeneTraffic, users easily control data access and permissions. Coupled with the database are robust tools for visualization and analysis of shared data.

CANVAC is a national effort with multiple centres nationwide. By implementing a dedicated Iobion Informatics' GeneTraffic Bioinformatics Server, CANVAC researchers from across the country have access to a central data storage site as well as powerful data analysis software. Users will be able to confidentially and securely access their data, perform data analysis, and even share data with other CANVAC members allowing potential collaborators to review each other's data from across the country.